Clinical Trials

The following is a list of Clinical trials by therapeutic areas which I have coordinated as Senior Statistician at the Hellenic Cooperative Oncology Group (HeCOG). Clinicaltrials.gov identifier in brackets

Lung Cancer

[8] ClinicalTrials.gov Identifier: NCT05372081 - SNF-CLIMEDIN: Digital support and intervention in patients with advanced NSCLC [Non-interventional]

  • Kosmidis, P., Kosmidis, T., Papadopoulou, K., Korfiatis, N., Vozikis, A., Lampaki, S., Psyrri, A., Fountzilas, E., Christopoulou, A., Samantas, E., Vagionas, A., Mountzios, G., Gkoumas, G., Tsoukalas, N., Athanasiadis, I., Bafaloukos, D., Panopoulos, C., Koufaki, M., Fountzilas, G., & Linardou, H. (2026). SNF-CLIMEDIN: A Randomized Trial of Digital Support and Intervention in Patients With Advanced Non–Small Cell Lung Cancer. A Hellenic Cooperative Oncology Group Study. Journal of Clinical Oncology: Clinical Cancer Informatics, Vol. 10, pp. e2500234. DOI

  • Kosmidis, P., Kosmidis, T., Papadopoulou, K., Korfiatis, N., Vozikis, A., Lampaki, S., Economopoulou, P., Fountzila, E., Christopoulou, A., Samantas, E., Vagionas, A., Mountzios, G., Gkoumas, G., Tsoukalas, N., Athanasiadis, I., Bafaloukos, D., Panopoulos, C., Koufaki, M., Petrakis, G., Fountzilas, G., & Linardou, H. (2026). Comprehensive Molecular Profiling of Advanced NSCLC in Greek Patients: A Prospective HeCOG Study. Cancer Treatment and Research Communications, Vol. 48, pp. 101310. DOI

  • Kosmidis, P., Kosmidis, T., Papadopoulou, K., Korfiatis, N., Vozikis, A., Lampaki, S., Economopoulou, P., Fountzila, E., Christopoulou, A., Samantas, E., Vagionas, A., Mountzios, G., Gkoumas, G., Tsoukalas, N., Athanasiadis, I., Bafaloukos, D., Panopoulos, C., Fountzilas, G., Petrakis, G., & Linardou, H. (2026). Association patterns among patient-reported adverse events in advanced NSCLC: A post-hoc analysis of the CLIMEDIN randomized controlled trial. Journal of Clinical Oncology, Vol. 44, No. 16_suppl, pp. e23271. DOI

  • Kosmidis, P., Kosmidis, T., Papadopoulou, K., Korfiatis, N., Vozikis, A., Lampaki, S., Psyrri, A., Fountzilas, E., Christopoulou, A., Samantas, E., Vagionas, A., Mountzios, G., Gkoumas, G., Tsoukalas, N., Athanasiadis, I., Bafaloukos, D., Panopoulos, C., Koufaki, M., Fountzilas, G., & Linardou, H. (2025). SNF-CLIMEDIN: A HECOG prospective randomized trial of digital support and intervention in patients with advanced NSCLC—Final results. Journal of Clinical Oncology, Vol. 43, No. 16_suppl, pp. 1515-1515. DOI

  • Kosmidis, P., Kosmidis, T., Papadopoulou, K., Korfiatis, N., Vozikis, A., Lampaki, S., Psyrri, A., Fountzilas, E., Christopoulou, A., Samantas, E., Vagionas, A., Mountzios, G., Gkoumas, G., Tsoukalas, N., Athanasiadis, I., Bafaloukos, D., Panopoulos, C., Koufaki, M., Fountzilas, G., & Linardou, H. (2025). Frequency of Adverse Events Reported Digitally by Patients with Advanced NSCLC: Analysis From CLIMEDIN, a HeCOG Study. Journal of Thoracic Oncology, Vol. 20, No. 10, pp. S392-S393. DOI

  • Kosmidis, P., Kosmidis, T., Papadopoulou, K., Korfiatis, N., Vozikis, A., Lampaki, S., Psyrri, A., Fountzilas, E., Christopoulou, A., Samantas, E., Vagionas, A., Mountzios, G., Gkoumas, G., Tsoukalas, N., Athanasiadis, I., Bafaloukos, D., Panopoulos, C., Koufaki, M., Fountzilas, G., & Linardou, H. (2024). SNF-CLIMEDIN: A prospective randomized trial of digital intervention in patients with advanced NSCLC—A HeCOG study. Journal of Clinical Oncology, Vol. 42, No. 16_suppl, pp. 1520-1520. DOI

  • Linardou, H., Kosmidis, T., Papadopoulou, K., Korfiatis, N., Vozikis, A., Lampaki, S., Psyrri, A., Fountzilas, E., Christopoulou, A., Samantas, E., Vagionas, A., Mountzios, G., Gkoumas, G., Tsoukalas, N., Athanasiadis, I., Bafaloukos, D., Panopoulos, C., Koufaki, M., Fountzilas, G., & Kosmidis, P. (2024). Analysis of evolution of patient reported side effects during treatment for advanced NSCLC. Annals of Oncology, Vol. 35, pp. S863-S864. DOI

  • Linardou, H., Kosmidis, T., Papadopoulou, K., Korfiatis, N., Lampaki, S., Psyrri, A., Fountzilas, E., Christopoulou, A., Samantas, E., Vagionas, A., Mountzios, G., Gkoumas, G., Tsoukalas, N., Athanasiadis, I., Bafaloukos, D., Panopoulos, C., Koufaki, M., Vozikis, A., Fountzilas, G., & Kosmidis, P. (2023). Clinical and molecular study with digital support of advanced non-small cell lung cancer patients: SNF-CLIMEDIN, a prospective randomized Hellenic Cooperative Oncology Group study. Annals of Oncology, Vol. 34, pp. S816-S817. DOI

[7] ClinicalTrials.gov Identifier: NCT03568097 - PAVE: Intercalated Avelumab plus platinum-based chemotherapy in patients with Extensive-Stage Small-Cell Lung Cancer [Phase II]

  • Linardou, H., Papadopoulou, K., Korfiatis, N., Goussia, A., Samantas, E., Aravantinos, G., Christopoulou, A., Spathas, N., Fountzilas, E., Psyrri, A., Koliou, G., Meditskou, S., Kosmas, E., Bobos, M., Charchanti, A., Vamvakaris, I., Koumarianou, A., Bafaloukos, D., Kosmidis, P., Fountzilas, G., & Mountzios, G. (2025). Intercalated Avelumab plus platinum-based chemotherapy in patients with Extensive-Stage Small-Cell Lung cancer (PAVE): Final outcome, immunophenotypic and biomarker analysis of a multi-center phase II Hellenic Cooperative Oncology Group study. European Journal of Cancer, Vol. 228, pp. 115660. DOI

  • Mountzios, G., Papadopoulou, K., Korfiatis, N., Goussia, A., Samantas, E., Aravantinos, G., Christopoulou, A., Spathas, N., Fountzilas, E., Psyrri, A., Koliou, G., Meditskou, S., Kosmas, E., Bobos, M., Charchanti, A., Vamvakaris, I., Koumarianou, A., Bafaloukos, D., Kosmidis, P., Fountzilas, G., & Linardou, H. (2024). Final outcome, immunophenotypic and biomarker analysis of intercalated avelumab plus platinum-based chemotherapy in patients with extensive-stage small cell lung cancer (PAVE). ESMO Open, Vol. 9, pp. 102770. DOI

Colorectal Cancer

[6] ClinicalTrials.gov Identifier: NCT03311750 - A-REPEAT: Anti-EGFR re-challenge with chemotherapy in RAS wild-type advanced colorectal cancer [Phase II]

  • Sgouros, J., Eliades, A., Papadopoulou, K., Korfiatis, N., Papamichael, D., Fountzilas, E., Tsolaki, E., Achilleos, A., Tsangaras, K., Loizides, C., Oikonomopoulos, G., Makatsoris, T., Kypri, E., Ioannides, M., Koumbaris, G., Fountzilas, G., Patsalis, P., & Pentheroudakis, G. (2025). Anti-EGFR re-challenge with chemotherapy in RAS wild-type advanced colorectal cancer (A-REPEAT study): efficacy and correlations with tissue and plasma genotyping. ESMO Gastrointestinal Oncology, Vol. 7, pp. 100120. DOI

Pancreatic Cancer

[5] ClinicalTrials.gov Identifier: NCT03745430 - RACING: Ramucirumab combined with nab-paclitaxel and gemcitabine as first-line chemotherapy in advanced pancreatic adenocarcinoma [Phase I/II]

  • Papaxoinis, G., Sgouros, J., Korfiatis, N., Papadopoulou, K., Psyrri, A., Zarkavelis, G., Ioannou, A., Petrakis, G., Kotsantis, I., Koumarianou, A., Fountzilas, E., Zagouri, F., Samantas, E., Fountzilas, G., & Pentheroudakis, G. (2026). Phase Ib-II Study of Ramucirumab Combined with Nab-paclitaxel and Gemcitabine as First-line Treatment in Patients With Advanced Pancreatic Adenocarcinoma (RACING). Cancer Treatment and Research Communications, Vol. 49, pp. 101481. DOI

Prostate Cancer

[4] ClinicalTrials.gov Identifier: NCT02512458 - CabaBone: Cabazitaxel in patients with castration-resistant prostate cancer and osseous metastases [Translational]

  • Liontos, M., Goussia, A., Korfiatis, N., Papadopoulou, K., Kanellis, G., Visvikis, A., Petrakis, G., Tsiatas, M., Fountzilas, E., Samantas, E., Fountzilas, G., & Efstathiou, E. (2025). The role of Cabazitaxel in Patients With Castration-Resistant and Osseous Metastases Prostate Cancer: A Hellenic Cooperative Oncology Group Phase II Study. Clinical Genitourinary Cancer, Vol. 23, No. 1, pp. 102253. DOI

Breast Cancer

[3] ClinicalTrials.gov Identifier: NCT05758948 - Germline and somatic pathogenic variants in patients with de novo metastatic breast cancer [Translational]

  • Fountzilas, E., Papadopoulou, K., Korfiatis, N., Goussia, A., Christopoulou, A., Moirogiorgou, E., Tsoukalas, N., Petrakis, G., Gouedard, C., Zagouri, F., Stefanou, D., Kyriakou, F., Vorrias, E., Karageorgopoulou, S., Dimitrakopoulos, F., Vernadou, A., Murray, S., & Fountzilas, G. (2026). Detection of germline and somatic pathogenic variants in patients with de novo metastatic breast cancer (dnMBC) and assessment of their prognostic relevance: A Hellenic Cooperative Oncology Group (HeCOG) translational cohort study. Clinical Cancer Research, Vol. 32, No. 4_Supplement, pp. PS4-02-18. DOI

  • Fountzilas, E., Papadopoulou, K., Korfiatis, N., Goussia, A., Christopoulou, A., Moirogiorgou, E., Tsoukalas, N., Petrakis, G., Gouedard, C., Zagouri, F., Stefanou, D., Kyriakou, F., Vorrias, E., Karageorgopoulou, S., Dimitrakopoulos, F., Vernadou, A., Murray, S., & Fountzilas, G. (2025). Detection of germline and somatic pathogenic variants in patients with de novo metastatic breast cancer (dnMBC) and assessment of their prognostic relevance: A Hellenic Cooperative Oncology Group (HeCOG) translational cohort study. 48th Annual San Antonio Breast Cancer Symposium (SABCS). San Antonio, Texas. DOI

[2] ClinicalTrials.gov Identifier: NCT04829890 - Dose-dense sequential adjuvant chemotherapy in patients with resected high-risk breast cancer [Phase III]

  • Goussia, A., Dimitrakopoulos, F., Korfiatis, N., Koletsa, T., Batistatou, A., Kourea, H., Bobos, M., Papadopoulou, K., Charchanti, A., Bai, M., Tzaida, O., Petraki, K., Arapantoni-Dadioti, P., Psyrri, A., Gogas, H., Zagouri, F., & Fountzilas, G. (2025). Clinical outcomes and important prognostic biomarkers following dose-dense sequential adjuvant chemotherapy (dds-CT) in early breast cancer (eBC): Pooled-analysis of individual patient data. ESMO Open, Vol. 10, pp. 104621. DOI

[1] ClinicalTrials.gov Identifier: NCT07561346 - Clinico-pathological and genomic features of HER2-low early breast cancer [Translational]

  • Lakis, S., Tsolaki, E., Korfiatis, N., Goussia, A., Kourea, H., Batistatou, A., Bobos, M., Papadopoulou, K., Charchanti, A., Bai, M., Tzaida, O., Petraki, K., Arapantoni, P., Koletsa, T., Pectasides, D., Koutras, A., Kalapanida, D., Dimitrakopoulos, F., Aravantinou-Fatorou, E., Spathas, N., Psyrri, A., Gogas, H., Zagouri, F., & Fountzilas, G. (2026). Clinico-pathological and genomic features of HER2-low early Breast Cancer (eBC). Results of retrospective analysis of seven adjuvant trials by the Hellenic Cooperative Oncology Group (HeCOG). Clinical Cancer Research, Vol. 32, No. 4_Supplement, pp. PS4-01-20. DOI

  • Lakis, S., Tsolaki, E., Korfiatis, N., Goussia, A., Kourea, H., Batistatou, A., Bobos, M., Papadopoulou, K., Charchanti, A., Bai, M., Tzaida, O., Petraki, K., Arapantoni, P., Koletsa, T., Pectasides, D., Koutras, A., Kalapanida, D., Dimitrakopoulos, F., Aravantinou-Fatorou, E., Spathas, N., Psyrri, A., Gogas, H., Zagouri, F., & Fountzilas, G. (2025). Clinico-pathological and genomic features of HER2-low early Breast Cancer (eBC). Results of retrospective analysis of seven adjuvant trials by the Hellenic Cooperative Oncology Group (HeCOG). 48th Annual San Antonio Breast Cancer Symposium (SABCS). San Antonio, Texas. DOI